The 52-year-old actor is best known for his role as the Marvel Comics character in the movie trilogy and has admitted there's a chance he could reprise the part.
He said: '''Blade 4' is controlled by Marvel and we did have a really productive and a wonderful meeting and we discussed a number of things.
''I don't know where it's on their schedule at this point, that hasn't been decided. I guess it's still up in the air.''
Regardless of whether a new 'Blade' movie comes to fruition, Wesley said there's a chance the character could appear in another Marvel movie.
He explained: ''I've always been a fan of these pieces and adaptations and I'd be nice to be a part of the family again.
''But if we don't to a Blade 4 or something else with Marvel, we'll do something else.''
The original 'Blade' movie was released in 1998 and was Marvel's first significant box-office hit.
Since then, however, the movie studio has enjoyed incredible success with some of its other comic book characters, such as Iron Man and Captain America.