The former Barcelona coach Tito Vilanova has died of throat cancer at the age of 45.

The club's official Twitter feed tweeted: "The FC Barcelona is in immense mourning. Tito Vilanova has died at the age of 45. May he rest in peace."

Vilanova took over at the Camp Nou ahead of the 2012-13 season having been Pep Guardiola's assistant during the most successful period in the club's history during which they won three out of four La Liga titles and two Champions Leagues in 2009 and 2011.

Barça went on to make the best-ever start to a La Liga season with 18 wins from 19 games but in December 2012 Vilanova was diagnosed with cancer for the second time. It meant that his assistant Jordi Roura was forced to take charge of the team on occasions when he was undergoing treatment.

At the end of the season Vilanova announced he was resigning to concentrate on his recovery from the illness.

Josep Maria Bartomeu, the president of Barcelona, expressed his condolences on Twitter: "Tito Vilanova was a wonderful person, and will never be forgotten at FC Barcelona. Thank you for everything you taught us. Rest in peace."

RIP